The systemic injection is a very effective method for combating nutrient deficiency. The chemicals flow throughout the tree to provide control of pests. Fertilizer and tree growth regulators can also be applied through injections made into healthy xylem. However, dead or diseased xylem is not functional, and the tree is beyond the help of systemic therapy. Successful control of tree pests is dependent upon delivering the pesticide to the infested parts of the tree.

One way this is accomplished is by systemic placement of pesticides into the sap stream of the tree. The method is done by drilling small holes into the tree at the root flare and installing capsules every 6 inches around the base. The material is then dispersed up the tree from the sap. The proper time to inject is at bud swell. It is environmentally safe and effective.